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The following message was posted to: PharmPK
Hi:
One of our drugs when given orally shows around 5-30 % renal clearance
in
monkeys in 48 hours. However, when given IV it does not show up in the
urine collected till 48 hours. We suspect enterohaptic recirculation
taking place when administered PO. I will appreciate if some member
explains some possible reason for the drug not showing up in urine when
administered IV.
Thanks
Ananda
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Hi Ananda,
Please excuse my direct intervention.
The facts presented in your e-mail seems to me to fit the behaviour of
a metabolite and not the behaviour of a parent drug.
Are you sure that you measure in the urine the original chemical
compound, the drug, and not a metabolite?
radu
Radu D. Pop
Director Biopharmaceutics
Pharma Medica Research Inc.
966 Pantera Drive
Mississauga, Ontario
Canada, L4W 2S1
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The following message was posted to: PharmPK
Hi Radu:
Thanks for your suggestion. Following oral administration we do measure
the parent drug (an ester) and its metabolite (an acid) in plasma, but
mostly the parent drug in urine. However, when we give the same drug
IV, we can measure both the parent and the metabolite together in
plasma, but we do not get any in urine.
Thanks
Ananda
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