Back to the Top
Dear All,
I am doing some prodrug stability studies employing a commercial liver
esterase. I have a question regarding the calibration curve for the
prodrugs. Do I have to employ for the calibration the same conditions
including the presence of the (inactivated) enzyme? Or are the
incubation buffer + cosolvent used to dissolve the drug enough?
Federica
Back to the Top
Dear Federica,
I think it is better to do in presence of inactivated enzyme.
Samiulla
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)