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Dear all,
We have developed some PK models for transdermal absorption (gel and
patch formulations) in adults.
We want now to use these models to simulate the PK plasma profiles when
applying these formulations to children.
Does anyone have relevant informations or references on the key
parameters (Vd, CL, body surface area, skin permeability, others?...)
that should be taken into account and on the way these parameters have
to be "scaled"?
Many thanks in advance for your help,
Fabrice Nollevaux,
SGS Biopharma - Biometrics Department
Vieux Chemin du Poete 10
B-1301 Wavre (Belgium)
www.sgsbiopharma.com
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The following message was posted to: PharmPK
See message below for aricle that has a great deal of pediatric
information
Dave
PharmPK - Discussions about Pharmacokinetics
Pharmacodynamics and related topics
The following message was posted to: PharmPK
Anja,
You may find some relevant information in a report of our institute,
which
was written by my colleague, dr. Loeckie de Zwart. You can find the
pdf of
this report at the website of our institute:
http://www.rivm.nl/bibliotheek/rapporten/623860011.html
Please contact me if you need/want a hardcopy of this report.
Regarding your question: Loeckie and co-authors concluded that
physiological differences were most pronounced up to 6 to 12 months of
age.
Kind regards,
ADrienne.
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