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Can anybody provide or point me to the calculations for this? Actual
code to compute this (any language) would be great
thanks
Ravi Kuppuraj
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[Can anybody provide or point me to the calculations for this? Actual
code to compute this (any language) would be great]
Dear Ravi,
Methods can be found in:
Yeh KC et al. in J Pharmacokinet Biopharm. 1989 Dec;17(6):721-40.
This method unfortunately is not completely sound because of the
(approximately) log-normal distribution of plasma concentrations and
therefore we stopped using it.
Alternatively you could do a mixed effects non-linear analysis (eg.
with
NonMEM or s-plus) to derive solid statistical conclusions.
Best regards,
Jeroen
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