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Dear Sir,
Please let me know whether the drug, CAPTOPRIL is highly variable drug
or not, when administerd orally.
Regards
Bollu Prasad
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Dear Prasad,
you wrote:
>Please let me know whether the drug, CAPTOPRIL is highly variable drug
or not, when administerd orally.
>
It depends ;-)
AUC - no
Cmax - yes
In three studies we have found for AUC an intra-subject CV of 11% - 18%
(geometric mean 16%); CV for Cmax was 35% (Cmax/AUC: 22%).
Steinijans et al.: Int.J.Clin.Pharmacol.Ther.33/8-1995 (428-430)
reported 16% for AUC and 31% for Cmax (Cmax/AUC: 26%).
from Zintzaras: Eur. J. Drug Metabol. Pharmacokin. 25-3/4 2000 (241-244)
a CV of 16% can be calculated for AUC.
Good luck,
Helmut
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Helmut Schutz
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