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Hi, all pharmacokinetists:
I'm interesting in cellular mathematic models for anticancer drugs.
I'm aware of
classic PK/PD models developed for corticosteroid or steroid by Jusko
et al.
can anyone suggest other models proposed particularly for anticancer
drugs including
antimetabolites, chelating agents so on?
Thank you all.
david
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Dear David
You could refer to
"Multiple - Pool Cell lifespan model of Hematologic Effects of
anticancer
agents" Krzyzanski et al., J Pharmacokinet Pharmacodyn. 2002
Aug;29(4):311-37.
Hope this helps.
Thank you
Mathangi
You could also refer to a recent reference from David D'Argenio's group:Back to the Top
Physiologically-Based Pharmacokinetics and Molecular Pharmacodynamics
of 17-(allylamino)-17-demethoxygeldanamycin and its Active Metabolite
in Tumor-Bearing Mice. J Pharmacokinet Pharmacodyn 2003;30:3:185-220.
Regards,
Rob Bies
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)