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Dear Mr.Fabrice,
The way you have explained the problem is owe some; in that case where
intra CV goes above 25 to 30% is it advisable to go for replicate
design? Instead of regular crossover design?. Can you explain me how to
determine the sample size in BE study when I know that with particular
sample size I am failing in CI. Its common that if you increase the
sample size we are trying to make the distribution wider but we need to
look in to the cost factor also ....going from 18 volunteers to say 30
to achieve the required CI will fetch hefty some of money.....
Please let me know your views
Thanks and Regards
ATUL
Novel Drug Delivery Systems
Glenmark Research Center
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)