Dear all group,Back to the Top
I want factor which used for the conversion of the human dose to the
rat dose depends upon the Body weight.
Please suggest me the same.
Thank you
Prashant
A good refernece for this type of allometric measurement isBack to the Top
'First-time-in-human dose selection:Allometric thoughts and
perspectives, by Boxenbaum and Dilea,J.Clin.Pharmacol.
35:957-966(1995). You should find there the adequate information,
there is other publications but this is the best one I can think of.
Jean-Pierre Moreau
An excellent conversion calculator can be found at:Back to the Top
http://www.fda.gov/cder/cancer/animalframe.htm
Cheers!
Jeffrey L. Larson, Ph.D.
Director of Toxicology and Pharmacokinetics
Tanox, Inc.
10555 Stella Link
Houston, TX 77025
(713) 578-4212
j_larson.aaa.tanox.com
I would recommend the "Dose Calculator" on the FDA website, whichBack to the Top
adjusts the dose based on relative body surface area.
http://www.fda.gov/cder/cancer/animalframe.htm
Of course, the real world result may differ.
Cheers,
/Kevin P. Foley, Ph.D.
Associate Director, In Vivo Biology
Synta Pharmaceuticals Corp.
45 Hartwell Avenue
Lexington, MA 02421 USA
Tel: 781-541-7231
Fax: 781-274-8228
E-mail: kfoley.-at-.syntapharma.com
http://www.syntapharma.com
http://myprofile.cos.com/kpfoley
Prashant,Back to the Top
Check out the following website. It has conversions for multiple
species.
Garry
http://www.fda.gov/cder/cancer/animalframe.htm
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