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In a bioavailability study of cetrizine (with both plasma and also urine
approach) we saw double, triple and even more peaks. In literature there is
not enough data about calculating different parameters of these products.
For example for calculating the percent absorbed how must we use the
Wagner-Nelson method. For evaluating excretion rate? How is better to
report the PK parameters. Ka1, Ka2,etc.. The intervariability is very high,
how can we compare test with reference. Usually in mean data all of these
differences disappear.
It is kind for proper suggestions which help us to so solve all of these
more systematically.
Dr. Sima Sadray, PhD
sadrai.-at-.sina.tums.ac.ir
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)