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Could someone remind me of the GFR value of a mouse please? say adult
MF-1/Balb-c strain
Thanks in advance
Simon Clark, M.Sc.
Analytical Pharmacology
Antisoma Research Laboratories
St Georges Hospital Medical School
Cranmer Terrace
London
SW17 0QS
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Hello Simon
You should find the information in here: Davies B and Morris T (1993)
Physiological parameters in laboratory animals and humans. Pharm Res
10:1093-1095.
Nicola F Smith, Ph.D
Cancer Therapeutics Branch
National Cancer Institute
Building 10, Room 5A01
9000 Rockville Pike
Bethesda MD 20892
United States
301-402-3622 (lab)
301-451-4978 (office)
smithni.-a-.mail.nih.gov
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Simon,
The infamous Davies & Morris (1993) paper (Pharmaceutical Research
10: 1093-1095) lists this value as 0.28 mL/min in a 20 g mouse (strain
unspecified). The authors give the original reference for this value
as King & Dedrick (1979) Cancer Treatment Reports 63:1939-1947.
I hope that this helps.
All the very best,
Bernard
Bernard Murray, Ph.D.
Senior Research Investigator
Drug Metabolism, PCS, PPD, GPRD, Abbott Laboratories, Chicago, USA
Bernard.Murray.aaa.abbott.com
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