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Dear all, How reliable would be percentage absorbed or oral
bioavailability calculation based on the data from urine. The urine
samples were collected for 24 hours (5 half lives). The drug is
excreted unchanged < 1% against the criteria of at least 10% for
reliable estimate. The drug was orally administered to rats and its
oral BA were approx. 20-25 %. The drug in question does not absorb more
than 20% from gastrointestinal tract. Best regards, Jagdish
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)