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I have plasma concentration data for a compound collected during a short
term infusion (multiple samples, 2 hour infusion). Plasma levels are not
at steady state. Post-infusion data is not available for complete data
analysis. IV bolus dose study indicates that the compound follows a
2-compartment PK.
Is there a way to calculate clearance and volume of distribution from
this truncated data?
Thanks
Raj
Raj Nagaraja, Ph.D.
Drug Safety and Disposition, DMPK
Millennium Pharmaceuticals, Inc.
45 Sidney St.
Cambridge, MA-02139
Ph: 617-444-1495
Fax: 617-444-1616
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Dear Raj,
I suggest that you model the combined data (infusion and bolus dose
studies) using a population approach.
Toufigh Gordi
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In view of Toufigh's response, I realize I should elaborate my question
a bit more:
In the absence of prior PK information, would it be possible to
determine basic PK parameters of a compound for which only short term
infusion phase (non-steady state) concentrations are available? The
example I mentioned earlier is a validation compound for which, prior PK
information is available.
Thanks
Raj
Raj Nagaraja, Ph.D.
Drug Safety and Disposition, DMPK
Millennium Pharmaceuticals, Inc.
45 Sidney St.
Cambridge, MA-02139
Ph: 617-444-1495
Fax: 617-444-1616
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