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Can you recommend guidelines or citations that lay out prospective
criteria for selecting plasma vs serum as a sampling matrix for small
molecules in PK studies? Also for large? There are theoretical
concerns about the change in protein binding with serum, but a look at
the archives suggests that this is not clearly or consistently a
problem.
Many thanks,
Paul
Paul Hutson, Pharm.D.
Associate Professor (CHS)
UW School of Pharmacy
777 Highland Avenue
Madison, WI 53705-2222
Tel: (608) 263-2496
FAX: (608) 265-5421
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)