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I'm looking for a review describing the renal excretion of drugs across
the
age range of pediatric patients/subjects (neonates, infants, children).
Any
general reviews on the ADME in these groups welcomed as well.
Thanks,
Dave
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"David Benziger"wrote:
>>"...I'm looking for a review describing the renal excretion of drugs
across
>the age range of pediatric patients/subjects (neonates, infants,
children).
> Any general reviews on the ADME in these groups welcomed as
well...">>
David:
You may try:
Byczkowski,J.Z. in: Exploration of Perinatal Pharmacokinetic Issues.
Risk Assessment Forum, Washington, DC, EPA/630/R-01/004, 2001.
Available on line:
http://cfpub2.epa.gov/ncea/raf/recordisplay.cfm?deid=29420
Or download:
http://oaspub.epa.gov/eims/eimscomm.getfile?p_download_id=120867
I hope it may help you.
Best wishes.
Janusz Z. Byczkowski, Ph.D.,D.Sc.,D.A.B.T.
Consultant
212 N. Central Ave.
Fairborn, OH 45324
voice (937)878-5531
e-mail januszb.aaa.AOL.com
homepage: http://members.aol.com/JanuszB/index.html
JZB Consulting web site: http://members.aol.com/JanuszB/consult.htm
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Here's a reference I've found useful:
http://toxsci.oupjournals.org/cgi/content/full/66/2/185
Here's a link to their data (click on "Child/Adult/Elderly Databases"):
http://www2.clarku.edu/faculty/dhattis/#Child/Adult/Elderly%20Databases
Gene M. Williams, Ph.D.
Senior Reviewer/Pharmacometrics Scientist
CDER/FDA
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Dave,
In addition to Gene's references this might also be a useful reference
for
you:
de Zwart LL, Haenen HEMG, Versantvoort CHM, Wolterink, van Engelen JGM,
Sips AJAM. Role of biokinetics in risk assessment of drugs and
chemicals in
children. Regulatory Toxicology and Pharmacology, 2004; 39: 282-309.
Please let me know if want to have a hardcopy of this publication.
Adrienne
AJAM Sips, PhD head department Method and Model development
National Institute of Public Health & the Environment
Center for Substances and Integrated Risk Assessment, U339
P.O. Box 1
3720 Bilthoven
The Netherlands
tel. + 31 30 274 2043
fax. + 31 30 274 4475
e-mail: adrienne.sips.-a-.rivm.nl
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