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The following message was posted to: PharmPK
We are trying to find a method or software implementation to calculate
the standard errors for AUC's obtained with destructive plasma samples
(4 samples for each time point, 1 sample per rat). We can do it with
Monte Carlo simulation but I was wondering if there are PK packages
that calculate the s.e. directly.
Thanks.
Tomas.
Tomas Martin-Jimenez, DVM, PhD
Assistant professor of Clinical Pharmacology
UIUC - Department of Veterinary Biosciences
2001 S. Lincoln Ave
Urbana IL 61802
Ph: 217-333-6742
Fax: 217-244-1652
Email: martin6.-at-.uiuc.edu
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You can use the method of Bailer found in J. Pharm. Biopharm.
16(3):303-309 (1988) for calculating the variability in AUC obtained
when using destructive sampling techniques. It is simple and can be
done with Excel.
Nathan
Nathan S. Teuscher, Ph.D.
Clinical Pharmacokinetics
NPS Pharmaceuticals
420 Chipeta Way
Salt Lake City, UT 84108
Tel: (801) 584-5379
Fax: (801) 583-2590
Email: nteuscher.aaa.npsp.com
Website: www.npsp.com
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The following message was posted to: PharmPK
But if you have more than a sample for each animal
and, then, there is some degree of correlation between
those data in the same animal, you should have it into
account.
look for the papers of DJ. Holder
Holder DJ, Hsuan F, Dixit R, Soper K
A method for estimating and testing area under the
curve in serial sacrifice, batch, and complete data
designs.
J Biopharm Stat. 1999 Aug;9(3):451-64.
PMID: 10473031 [PubMed - indexed for MEDLINE]
Comments on Nedelman and Jia's extension of
Satterthwaite's approximation applied to
pharmacokinetics.
J Biopharm Stat. 2001 Feb-May;11(1-2):75-9.
PMID: 11459444 [PubMed - indexed for MEDLINE]
we are developing an application to peform those
calculations for different experimental designs
Marival Bermejo
mbermejo.-a-.uv.es
Universidad de Valencia
Espana
phone +34 96 3544916
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)