I am interested in knowing which CYPs are responsible for verapamilBack to the Top
metabolism in male rat liver ? (I know in humans 3A4 and 1A2 are
involved)
Many Thanks,
Seb
Sebastian Hallworth
Tel: +44 1625 510646
This references might help:Back to the Top
- The Journal of Pharmacology And Experimental TherapeuticsVol. 305,
Issue
1, 151-158, April 2003. A Kinetic Evaluation of the Absorption, Efflux,
and Metabolism of Verapamil in the Autoperfused Rat Jejunum
Brendan M. Johnson, Weiqing Chen1 , Ronald T. Borchardt, William N.
Charman and Christopher J. H. Porter
- Sun L et al / Acta Pharmacol Sin 2004 Jan; 25 (1): 121-128
In vitro identification of metabolites of verapamil in rat liver
microsomes1 Lu SUN, Shu-qiu ZHANG, Da-fang ZHONG2
(http://www.chinaphar.com/1671-4083/25/121.htm)
(found through a quick look on google with "verapamil metabolism in
rat")
Hope it helps
Facundo Garcia Bournissen.
facugb3.-at-.hotmail.com
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