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My recommendation would be to spend the extra money on the BDC animals
and get worthwhile data that can be used. The use of the intact model
will also enhance any comparisons that you would wish to make with any
model compounds. A properly designed BDC study will go much further
than the timed bile collection by gall bladder drainage. You would have
to make too many assumptions on bile production, transport and storage
in the gall bladder to make it worth your efforts.
Kind regards,
sanjeev
Sanjeev Thohan, PhD
South San Francisco, CA 94083
sthohan.-at-.exelixis.com
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)