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Dear All,
I am trying to model pharmokinetic behaviour of Amiodarone. The drug
has a variable half life, is extensively distributed and retained in
body tissues. The half life increases with duration of dosing, it is a
substrate for P-gp and CYP3A4. I was wondering if anybody had
experience working with this drug and can give suggestions.
Regards
Varun Goel
Graduate Student
Mass College of Pharmacy
Boston, MA
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Varun,
Amiodarone probably belongs to the class of molecules called
hydrotropes. This class exhibits a specific type of liquid crystal
behavior which is characterized by associating in water and so
retaining aspects of its solid structure. See, for example, Aggregation
Behavior of Hydrotropic Compounds in Aqueous Solution, Balasubramanian,
D. et.al. J. Phys. Chem. 1989, 93, 3865-3870. Hydrotropes are related
to, but distinct from, surfactants. Hydrotropes are known to interact
with surfactants, such as bile salts, to form "worm-like" mixed
micelles.
Regards,
Frank
Frank Bales, Ph.D.
Phone: 847-537-5423
910-655-9660
Email: frankbales.aaa.msn.com
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