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Dear Maralee,
I suggest instead of going for B of HP B you
should have to go for sulfobutyl derivative of cyclodextrin. This
derivative is almost free from the toxic effeces of CD. and it is
approved for the IV formulations also.
Tushar Nahata
Deptt of Pharmacy
SGSITS
23,Park Road
Indore (MP)
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Dear Ravi kanth,
In your previous post to pharmpk, i got the information regarding
volume expansion when using cyclodextrin formulation.
I have a doubt:
I want to dissolve "X" mg of the compound in certain volume of the
vehicle containg HPBCD.
initially added compound and HPBCD and certain volume of water (say
2ml), i can see an increase in the volume (2.5ml), now i want the
concentration of the compound in such a way that the total volume of
vehicle addition should be 4ml, now my question is do i have to add
remaining 2ml or should i add 1.5ml? how are we considering the
increase in volume due to HPBCD?
hope my question is clear to you.
Regards,
Suresh.B.L
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The following message was posted to: PharmPK
Dear Suresh,
You can find data on the volume expansion of aqueous HPBCD and
HPBCD-drug complex solutions
at:www.cyclodex.com
It is around 1.0 ml/gram at low (5%w/v) concentrations, the magnitude
of the effect levels off at about 0.7 ml/gram at concentrations greater
than 20% w/v.
No considerable further volume expansion occurs after dissolving
several mg drug substances in HPBCD solution.
If the total volume of vehicle (HPBCD solution) you need is 4 ml, you
should add 1.5 ml of water.
Best regards, Maria Vikmon,
former researcher at Cyclolab, Cyclodextrin R&D Ltd, Budapest,Hungary
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