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The following message was posted to: PharmPK
Dear all,
For proceeding in Invitro In vivo correlation for a formulation of
Domperidone,mebendazole,chloroquine. I need to know the class of
Biopharmaceutical classificaiton system in which all these drugs may
belong.
I searched the internet, but couldnt find any relevant material.
If anyone can suggest some means of finding this information, It
would be of
great help to me.
Thanks in advance,
Regards
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The following message was posted to: PharmPK
Basant: This reference will be an excellent resource:
"Molecular Properties of WHO Essential Drugs and Provisional
Biopharmaceutical Classification"
Kasim et al., Mol. Pharm. 2003, 1 (1), 85-96.
Sunil
--
Sunil S. Iyer, M. Pharm.
Ph.D. Candidate
Department of Pharmaceutics
Virginia Commonwealth University - School of Pharmacy
PO Box 980533
410 North 12th Street
Richmond VA 23298-0533
Phone: (804) 828-6214
Fax: (804) 828-8359
e-mail: iyerss.-a-.vcu.edu
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The following message was posted to: PharmPK
The correct reference is:
Molecular Properties of WHO Essential Drugs and Provisional
Biopharmaceutical
Classification
Kasim, N. A.; Whitehouse, M.; Ramachandran, C.; Bermejo, M.;
Lennernas, H.;
Hussain, A. S.; Junginger, H. E.; Stavchansky, S. A.; Midha, K. K.;
Shah, V.
P.; Amidon, G. L.
Mol. Pharm. 2004, 1(1), pp 85-96.
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The following message was posted to: PharmPK
Dear Basant,
Review article of M. Lindberg, S. Kopp and J.B. Dressmann:
Classification of orally administered drugs on the WHO model
list of Essential Medicines according to BCS (European
Journal of Pharmaceutics and Biopharmaceutics, 58, (2004)
265-278) ranking mebendazole to BCS class II/IV,
because of inconclusive data regarding its permeability.
No ranking for domperidone and chloroquine can be found in
the review.
Solubility and logP data of these drugs taken from
Drugbank database:
(http://redpoll.pharmacy.ualberta.ca/drugbank/)
Domperidone: solubility: 0.986mg/L, logP: 2.527
Chloroquine: Solubility: 10.6 mg/L, (its phosphate and
hydrochloride salts are freely soluble in water!), logP: 4.474
I hope that it could help to you,
Best regards, Maria Vikmon
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