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Hi,
In a screening program, we used to determine the bioavailability of
new compounds following oral and IV administrations. However, it was
suggested to base the first selection of compounds on historical AUC
values obtained following oral administration of other compounds
(same chemical class and same dose) and then to determine the F by
administering the drug by IV. From a PK point of view, it seems
likely that this approach has many limitations because we have to
assume that the drugs behave the same in terms of distribution,
elimination...In another hand, it seems that this is a common
approach to enhance drug discovery in pharmaceutical companies.
Your feedback is always appreciated,
Thanks,
Samia
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)