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The following message was posted to: PharmPK
Dear all,
I need to simulate the plasma concentration profile from the one
compartmental model considering the intra and inter variability in
the ke and ka and residual error.
You know any software or procedure that permit to perform this
simulation ?
Thanks,
Elsa Costa, MSc
Pharmacokinetic Assessor
INFARMED- Pharmaceutical Department
Av. do Brasil 53, Edificio Tome Pires 1749-004 Lisboa (Portugal)
Tel: +351 21 798 7271 Fax: +351 21 798 7248
elsa.costa.aaa.infarmed.pt
[For a general approach I would think a Monte Carlo simulation might
be the best approach. A number of programs, listed on http://
www.boomer.org/pkin/soft.html should be capable of doing this. I have
used Boomer (http://www.boomer.org/) for this sort of exercise,
although it requires some post-processing using a spreadsheet to
provide a concentration versus time plot with error bars or
confidence intervals. - db]
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Dear Elsa,
I think our pharmacokinetics data analysis program, PK Solutions,
will do what you need. You are invited to visit our website at
www.SummitPK.com where you can download a demo of the program, take a
detailed tour of the functions and features, obtain a user guide and
other materials to help you evaluate whether this is what you need.
I'll be glad to answer any questions you may have.
Best Regards,
David S. Farrier, Ph.D.
/\ /\
SummitPK.com /\ / \ /\ / \
/ / / /\ / \
=David S. Farrier, Ph.D. Phone: 970-249-1389
Summit Research Services Fax:: 970-249-1360
68911 Open Field Dr. Email: DFarrier.aaa.SummitPK.com
Montrose, CO 81401 Web: http://www.SummitPK.com
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The following message was posted to: PharmPK
Elsa,
This can be done using Microsoft Excel if you know how to write the
PK model. Random error can be added to parameters using Parameter*EXP
(NORMINV(rand(),0,ppv)) with variability log normal SD of ppv and to
concentrations using NORMINV(rand(),0, ruv) with residual error SD of
ruv.
There are many other ways to do this e.g. NONMEM, Splus, SAS, etc.
If you want to do this sensibly I recommend using physiological
parameters like clearance and volume rather than rate constants like Ke.
Nick
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
Zealand
email:n.holford.-a-.auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
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The following message was posted to: PharmPK
Dear Elsa
Why don't you use ADAPT-II and its SIMUL routine.
Although I remember showing it to you long time ago, it is still
available free of charge by the Biomedical Simulations Resource at
the University of Southern California. You may even want to check out
the new S-ADAPT version with additional simulation and optimization
abilities.
Best Wishes
Luis
--
Luis M. Pereira, Ph.D.
Assistant Professor, Biopharmaceutics and Pharmacokinetics
Massachusetts College of Pharmacy and Health Sciences
179 Longwood Ave, Boston, MA 02115
Phone: (617) 732-2905
Fax: (617) 732-2228
Luis.Pereira.at.bos.mcphs.edu
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The following message was posted to: PharmPK
Dear Elsa,
For a lot of good reasons you should use NONMEM.
Best regards.
Amilcar Falcao; PharmD, PhD
Laboratory of Pharmacology
Faculty of Pharmacy
University of Coimbra
3000-295 Coimbra
Portugal
E-mail(1): acfalcao.-at-.ff.uc.pt
E-mail(2): acfalcao.aaa.4health.pt
Phone: +351.239855092
Fax: +351.239855099
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