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Two different preparations of monoclonal antibodies were reconstitued
in PBS at approximately 20 mg per 10-11.5 mL. These volumes were
injected via the marginal ear vein as a bolus. The concentrations
(in mIU/mL) in plasma peaked around 0.5 hr and then declined. Any
thoughts on late Tmax?
Dave
IV Form 1
Animal # 1 2 3 4 MEAN SD
IU/mL
hr
0 0 0 0 0 0 0
0.25 153 126 121 164 141 21
0.5 338 241 355 448 346 85
1 185 183 209 181 189 13
3 137 157 143 132 142 11
IV Form 2
Animal # 6 7 8 9 MEAN SD
IU/mL
hr
0 0 0 0 na 0 0
0.25 77 145 166 na 129 46
0.5 172 287 311 na 257 74
1 156 176 110 na 147 34
3 100 150 138 na 130 26
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)