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The following message was posted to: PharmPK
Dear group,
Please could you clarify which of the following
equations is appropriate to calculate intrinsic
clearance values in in-vitro metabolic stability
studies although they both are same?
Clint = Vx k
Clint = V x 0.693/(t1/2)
I understand that we get the second equation by
substituting k= 0.693/(t1/2).
Thanking you in anticipation,
CALI
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)