PharmPK Discussion - Measurement of Pegylated Interferon alpha 2a and 2b in plasma/serum

• On 28 Nov 2005 at 16:41:58, "DANI FARRE" (danifarre.aaa.hotmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi all
  
  I'm interested in measuring concentrations of Pegylated interferon
  alpha 2a and 2b in HCV infected subjects in treatment with any of
  this two drugs.
  Did anybody knows if there is any kit ELISA commercialized for doing
  that?
  
  Thanks
  Daniel Gonzalez de Requena, Pharm D
  
  University of Turin. Italy
  
  

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• On 28 Nov 2005 at 10:48:21, "Tarnowski, Tom" (tom.tarnowski.aaa.roche.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  I am not aware of any commercial ELISA that will reliably determine
  concentrations of pegylated interferon alpha 2a (Pegasys(r) from Roche)
  or 2b (PegIntron(r) from Schering).
  
  Thomas L. Tarnowski, Ph. D.
  
  Project Team Leader
  Dept. Head, Drug Metabolism and Pharmacokinetics
  Roche Palo Alto
  3431 Hillview Avenue, Palo Alto, CA 94304
  * Phone: (650) 852-3182
  *  FAX:   (650) 855-6428
  * email  tom.tarnowski.aaa.roche.com
  
  

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• On 29 Nov 2005 at 09:25:24, "DANI FARRE" (danifarre.at.hotmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hello Tom,
  
  have Roche any method for measuring Pegasys concentrations? I have
  found some published studies (phase I/II) that described an ELISA
  assay developed by Hoffman-La roche. It was possible to obtain some
  kits to evaluate it in clinical practice?
  
  Reference:
  Motzer RJ, Rakhit A, Ginsberg M et al. Phase I Trial of 40 Kd
  Branched Pegylated Interferon Alfa 2a for patients With advanced
  Renal Cell Carcinoma. Journal of Clinical Oncology 2001; 19(5):1312-1319
  
  Thanks
  
  

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