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Dear members,
I would appriciate to know if there is any specific methodology
(similar to that of f1and f2 statistics used in dissolution profiles
comparison) to compare two different (e.g., entirley different
studies utilising unequal number of subjects but same formulation
through same route) plasma conc-time profiles (data).
Thanks
ashokraj
Dr. Y. ASHOKRAJ,
Manager, NDDS, Pharma R&D,
Nicholas Piramal Research Centre,
1, Nirlon complex, Off western Highway,
Near NSE Complex, Goregaon (E),
Mumbai-400 063, India
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The following message was posted to: PharmPK
Hi,
I would recommend our study:
Dedik, L., Durisova, M.: System-approach methods for modeling and
testing similarity of in vitro dissolutions of drug dosage
formulations.
Computer Methods and Programs in Biomedicine, 69, 2002, 49-55.
I want to stress that the method described in this study is not
similar to that of f1 and f2 statistics.
However, this method fulfils the requirements given in your message.
Maria Durisova, DSc., (Math/Phys)
Vice Director and
Head of Department of Pharmacokinetics
Institute of Experimental Pharmacology
Slovak Academy of Sciences
841 04 Dubravska cesta 9
http://www.uef.sav.sk/advanced.htm
Bratislava
Slovak Republic
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