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Hi,
Does anyone have an idea if P-gp expression or activity is
gender-related in humans or rodents? some papers (Schwartz, Clin
Pharmacokinet, 2003 and others) asked the same questions but didin't
give a clear answer.
Thank you in advance.
Best regards
Makrem BEN REGUIGA
PharmD, PhDs
Paris, France
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The following message was posted to: PharmPK
Abstract PD-5 from the ASCPT meeting CPT Vol 77(2) 2005 M.F.Paine et
al.
n=46 men and 45 women.
Duodenal biopsies
Found no sex difference in expression of CYP3A4 (varied 8-fold), Pgp
(varied 10-fold) or CYP3A5 (varied 7-fold).
No sex difference in pre-menopausal women <45 y (n=21) vs men <45 y
(n=43)
No difference in Pgp for pre and post menopausal women.
A non-significant (p=0.01) 20% decrease of CYP3A4 in post-menopausal vs
premenopausal women.
Susan Shoaf
Sr. Pharmacokineticist
Otsuka Maryland Res. Inst.
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