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The following message was posted to: PharmPK
Dear All,
Please could any body provide references for oral
absorpation of propranolol and atenolol in humans.
Many thanks.
CALI
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The following message was posted to: PharmPK
Propranolol has high oral absorption (~70%), while atenolol is a classic
example of passively not well absorbed compound (I have the numbers but
not at hand).
Katya Tsaioun, Ph.D.
In vitro ADME
NitroMed, Inc.
125 Spring Street,
Lexington MA 02421
781-266-4214 (office)
ktsaioun.at.nitromed.com
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The following message was posted to: PharmPK
Cali:
Atenolol is a highly soluble low permeable drug (BCS class 3) (26.5
mg/mL,
log p 0.50 C logP = -0.11) propranolol hcl is Highly soluble and highly
permeable drug (BCS Class 1) , log p 2.65 and C logP = 2.75)
Solubility 33
mg/mL
Ref: Modern Pharmaceutics 2004 Vol 1 85-96 and Eur J Pharm and Biopharm
2004, 58, 265-278
Hope this helps.
Prasad Tata
Saint Louis, MO 63134
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