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I have a question regarding the application of Bailer's method in the
estimation of the variance of AUC for destructive sampling design.
For IV studies, The plasma conc at time zero is not measured but can
be calculated by extrapolation of the naive averaging profile.
Consequently, there is a single value for that conc and no associated
variability. Ignoring the variability of C0 will result in
underestimation of the variance of AUC.
Is there a way to overcome that or Bailer's method can only estiamte
the variance of AUC from the first sampling point to the last and not
from time zero in case of IV dosing??
I will appreciate any comments or explanation.
Thanks
Ahmed Abdel-Fattah Othman.
Ph.D. Candidate.
Pharmacokinetics and Biopharmaceutics lab
School of Pharmacy.
University of Maryland at Baltimore.
20 Penn Street.HSF-2
Baltimore, MD 21201
Phone:(410)706-7388
E-Mail:- aothm001.aaa.umaryland.edu
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The following message was posted to: PharmPK
Dear Ahmed
A variability of the C0 can be estimated, because C0 is computed on a
basis of measured concentrations for which variability can be estimated,
so it can also be calculated for the extrapolating expression. You may
find a simple way how to do it in my paper:
Jawien W. Variability of the model-independent AUC: the one sample per
individual case. Journal of Pharmacokinetics & Biopharmaceutics.
27(4):437-64, 1999 Aug.
Best regards
Wojciech Jawien
Jagiellonian University, Faculty of Pharmacy
Dept. of Pharmacokinetics
30-688 Krakow
ul. Medyczna 9
Poland
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