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The following message was posted to: PharmPK
Hello,
I am analytical chemist, working on polychlorinated biphenyl (PCB)
concentrations in mice tissues.
I recently wanted to express my data as % of dose given to animals,
in different organs.
For lipophilic compounds, like PCBs, adipose is the most important
organ, with the highest content.
However, it seems to be tricky to determine how much of adipose
tissue is really in the animal, so I didn't have the value from my
experiment.
I already found some approximate values used in pharmacokinetics, but
for both adipose and blood there are only volumes, but I need masses.
Can anybody advice on that? I could use density values to re-
calculate, too, if it is an option, but these I cannot find either.
Thanks,
Izabela Korwel
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The following message was posted to: PharmPK
Izabela,
Usually, a constant density of 1 kg/L is assumed for all organs.
Fat contents in the mouse is in the 5-14% bodyweight range.
You will find all physiological parameters you need in the following
references :
Davies B and Morris T (1993) Physiological parameters in laboratory
animals and humans. Pharm.Res. 10:1093-1095.
Brown RP, Delp MD, Lindstedt SL, Rhomberg LR, and Beliles RP (1997)
Physiological parameter values for physiologically based
pharmacokinetic models. Toxicol.Ind.Health 13:407-484.
Regards,
Antoine DESLANDES, PhD
DMPK Senior Manager
CENTELION SAS
72-82 Rue Leon Geffroy
94408 VITRY SUR SEINE CEDEX
FRANCE
Phone (33).1.58.93.36.30
Fax (33).1.58.93.35.05
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