PharmPK Discussion - Assay of Drug in Plasma and Liposome Following IV Inj of Liposome Formulation

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On 27 Apr 2006 at 12:13:59, "Clerk Maxwell" (clerkmaxwell.at.hotmail.com) sent the message


The following message was posted to: PharmPK

Assuming a liposomal encased drug is intravenously injected, can
anyone provide a clinical research organization (CRO) or laboratory
that can assay drug separately within the liposome, as well as in the
plasma.  Thanks.  Harold.

Harold Boxenbaum, Ph.D.
Arishel Inc.
14621 Settlers Landing Way
North Potomac, MD 20878-4305
(P) 301-424-2806
(F) 301-424-8563
Email: harold.-at-.arishel.com

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On 27 Apr 2006 at 10:26:16, "Michael Chansler" (mchansler.at.acciumbio.com) sent the message


Dr. Boxenbaum,
If the compound is lightly labeled with 14C it would be possible to
measure concentrations in liposomes, blood and tissue using
Accelerator Mass Spectrometry. (AMS)  We have the only commercial AMS
available in the US for early drug development.

Michael Chansler
Vice President Business Development and Sales
Accium BioSciences
550 17th Avenue, Suite 550
Seattle, WA 98122
Tel: (206) 281-3915
Fax: (206) 281-5916

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