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I hope someone can help me.
I have 2 structurally similar compounds. I administered them in rats
by gastric infusion. One compound has a significantly longer
distribution phase than the other, but the T 1/2 are similar. What
would be the PK significance?
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Dear Carey:
Please be more specific as what do you mean by
significantly longer distribution phase? e.g., 2 min
vs 5 min or 2 min vs 20 min? Did you use the same
sampling time points for both compounds?
Correct/reasonable fitting? How many animals per
compound did you test? Do you have data on solubility
of these compounds? What formulation was used? Is the
Cmax similar for both compounds? Your question "What
would be the PK significance? Is a little confusing.
The PK significance of your observation would be in
terms of clearance (a hot topic these days) and
eventually AUC like any other drug. You should
probably think about the significance of your findings
in terms of pharmacology and toxicology (i.e.,
therapeutic window) rather than PK.
Rostam
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