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What is the physiological process for drugs with extremely high
volume of distribution (50-100 L / Kg in rat) and high clearance
100-150ml/min/kg? And shorter half-life of around 1-2hrs
Are these drugs taken up by softer tissues and then cleared rapidly,
possibility, these drugs are very soluble and fairly basic with PKa
of around 8-9.
Many thanks, much appreciated for the information
Regards
Mohammed
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