Back to the Top
hi
am working on glimepiride which is insoluble in water, my problem is
in vitro-dissolution testing of the drug formulation in media that
mimic gastro-intestinal fluid. i have tried SLS in acidic media but
drug is still insoluble in it. can you please suggest some other way
to solubilize the drug.
i will be highly grateful to you
from:
Neha Bhandari
M.Pharm student
DIPSAR
New Delhi
India
Back to the Top
The following message was posted to: PharmPK
Dear Neha,
The glimepiride is soluble on borate buffer pH 9.5.
Best Regards,
Elsa Costa, MSc
Pharmacokinetic Assessor
INFARMED- Pharmaceutical Department
Av. do Brasil 53, Edificio Tome Pires 1749-004 Lisboa (Portugal)
Tel: +351 21 798 7271 Fax: +351 21 798 7248
elsa.costa.-a-.infarmed.pt
Back to the Top
The following message was posted to: PharmPK
I suppose the solubility of glimepride increases with pH. The reason to
assume that is that it is absorbed quickly from the gastric mucosa.
It is indeed reported in an article published in
European Journal of Pharmaceutics and Biopharmaceutics 46 (1998) 305311,
that dissolution media for glimepride is phosphate buffer pH 7.8.
Hope this reference might of help.
--
R. Palpandi Raja, Research Scholar, Bioprocess Eng Lab, Chemical Eng
Dept,
IIT Bombay, Powai, Mumbai 400076. Tel: (022)25764227, Fax: (022)25726895
Back to the Top
Dear Neha,
You can find information of dissolution methods, including for
Glimepiride, at the site:
http://www.accessdata.fda.gov/scripts/cder/dissolution/index.cfm
Regards,
Paula Macedo Cerqueira, PhD
Pharmacist- Technical Consultant
National Health Surveillance Agency - ANVISA
Bioequivalence Unity - Sao Paulo -SP- Brazil
Back to the Top
The following message was posted to: PharmPK
As Glimepride is relatively more hydrophobic use of SLS in phosphate
buffer at higher pH could enhance the dissolution.
Is it mandatory that in-vitro dissolution studies need to be
simulated to
gastric pH (stomach is the site of absorption for glimepride)
--
R. Palpandi Raja, Research Scholar, Bioprocess Eng Lab, Chemical Eng
Dept,
IIT Bombay, Powai, Mumbai 400076. Tel: (022)25764227, Fax: (022)25726895
PharmPK Discussion List Archive Index page
Copyright 1995-2010 David W. A. Bourne (david@boomer.org)