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The following message was posted to: PharmPK
Hi all,
I've tried to search for the corrected definitions of the relevant
kinetic parameter for a pre-clinical study (28-day by i.v. infusion).
Would you please help me on the definitions of AUC, etc., etc. and
timing of blood collection.
Best regards,
Dario
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The following message was posted to: PharmPK
Dear Dario,
In a 28-day IV infusion study you would determine the following PK
parameters- Cmax, AUClast, AUCinf, T1/2 (half-life), Clearance plasma
and Vss (Volume of distribution).
Regarding timing of blood collection-
You should collect blood sample during infusion and at the end of
infusion.
Other time points may be determined based on T1/2 of your drug (3-5
T1/2.
Any other valuable suggestions from the group would be appreciated
Rgards
Tausif Ahmed, Ph.D.
India
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