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What chemical changes would you recomend for compounds with large
volume of distribution Vss in rat of 50L/kg and high clearance of
100-200ml/min/kg and short half life of around 1-2hr.
Many thanks
M. Yaqoob
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Hi,
I wonder if you had any solution yet. Does your compound have high
red blood cell binding, e.g. high blood-plasma ratio?
Regards,
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