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Dear all..
I will be happy, if anyone could clarify my doubt.
We are using "least square means" in bioequivelence
studies.
I observed that Arithmetic means and least square means
are equal.
What is relation between these two?
What is the formula for calculating LSM?
Regards,
Shekar.
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The following message was posted to: PharmPK
Hi,
For computing Arithmatic mean we consider the frequencies or weights.
While for computing Least square mean the frequencies are not
considered. They are assumed to be equal.
Hence when the frequencies are same AM=LSM. So in case of a
balanced
design when the number of sequences are same AM = LSM
Regards
Sulagna
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Hi..
Sulagna
Iam sorry to say that , Iam a bit confused with your answer.
Could you please explain your answer with bioequivalence example.
Regards,
shekar.
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ok,
Formula for AM n(A) + m(B) : Where n and m are
frequencies of A and B
----------
n+m
Formula for LSM A + B : Because in LM the frequencies
are not considered
-----
2
Therefore when n is equal to m then AM is A + B which is also
the LSM
----
2
Hence for balanced designs where number of subjects in both
sequences are same, the AM is equal to LSM
I hope I am clear now .......
Sulagna
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