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The following message was posted to: PharmPK
Hi,
I am looking for the equation to predict drug concentration in the
setting of multiple dosing IV bolus with 2-compartment model. My
search on the web is fruitless. I appreciate if anyone can help me
on this.
Thanks.
Andrew.
[Would Cp = A*((1-exp(-n*alpha*tau)/(1-exp(-alpha*tau))*exp(-alpha*t)
+ B*((1-exp(-n*beta*tau)/(1-exp(-beta*tau))*exp(-beta*t) work? - db]
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The following message was posted to: PharmPK
The equation is correct for the case of equal doses given at equal
intervals. Note that A and B include the Dose you give at each interval.
A=D(ALPHA-K21)/(V*(ALPHA-BETA))
B=D*(K21-BETA/(V*(ALPAH-BETA))
Serge Guzy
President POP-PHARM
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