PharmPK Discussion - Rabbit and dog hepatic and kidney blood flow

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On 26 Jan 2006 at 01:02:09, "Khalid Alkharfy" (alkharfy.-a-.ksu.edu.sa) sent the message


Dear Colleagues,
Does anyone know the values of hepatic and kidney blood flow of
animal species (rabbit and dog).

Thanks,
Khalid Alkharfy

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On 26 Jan 2006 at 16:29:02, =?ISO-8859-1?Q?MASSIERE_Frederic?= (frederic.massiere.at.oroxcell.com) sent the message


The following message was posted to: PharmPK

Khalid,

I've just picked up the following values (mL/min) from Davies B and
Morris T, Pharm Res 1993, 10:1093 :
- rabbit liver: 177
- dog liver: 309
- rabbit kidneys: 80
- dog kidneys: 216.

Hope that helps.
Regards,
Frederic Massiere

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On 26 Jan 2006 at 09:01:46, "Joyce James" (jjames.at.ambitbio.com) sent the message


The following message was posted to: PharmPK

Here is a good old reference for that and other physical measurements on
animals used in pharm models: "Physiological Parameters in Laboratory
Animals and Humans" by Brian Davies and Tim Morris, Pharmaceutical
Research, vol 10 no 7, 1993 (p. 1093-1095).

Specifically, hepatic blood flow for rabbit and dog is 177 mL/min and
309 mL/min, respectively, and kidney blood flow is 80 and 216 mL/min,
respectively.

-Joyce

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