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The following message was posted to: PharmPK
Dear Colleagues:
If after a single iv injection, tissue-to-plasma
concentration ratio stays constant over time (say up
to 8 h) we can suggest that steady state has been
achieved between plasma and that particular tissue
[drug concentration is declining in plasma and all
tissues after dosing]? I would like to know is there
any counter argument to this if that tissue happen to
be brain?
Rostam
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The following message was posted to: PharmPK
Dear colleagues: I would like to know what do you
(particularly tissue distribution experts) think about
these data.
Tissue:plasma conc. ratio over time for parent drug
(HPLC analysis)
Time(h) liver Kidney Heart Lung Intestine Brain
0.25 10.0 7.1 11.0 6.1 5.0 5.0
2 8.0 13.0 19.0 13.0 16.1 4.0
10 5.0 14.2 32.2 6.0 18.3 4.5
My interpretation of this data is that steady state is
achieved between plasma and brain tissues.
Rostam
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Copyright 1995-2010 David W. A. Bourne (david@boomer.org)