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The marker substrates for each UGT isoform is mostly available now
however, marker inhibitors for each UGT isoform is not available or
known.
Is it because marker inhibitors are not selective enough for each UGT
isoform?
Thank you,
Anila
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Dear Anila,
Yes, the reason is correct. Marker inhibitors for each isoform are
not selective enough. Therefore, identification and quantitation of
isoform contributing to metabolism cannot be done due to the lack of
selective inhibitors and inhibitory antibodies.
I hope this helps.
Best regards,
Sue
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