PharmPK Discussion - Can we do the Meta Analyis of Bioequivalence Studies

• On 1 Feb 2007 at 11:10:52, AMarwah.-a-.wockhardtin.com sent the message
  

  
  Dear Sir,
  
  Can we do the Meta Analyis of Bioequivalence Studies. Thanks.
  
  Regards
  Ashwani
  
  

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• On 1 Feb 2007 at 12:48:18, "Pereira, Luis" (Luis.Pereira.at.mcphs.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  Ashwani
  
  I guess the question is not so much whether you can, but rather
  whether you should. It's always possible to pool data and treat them
  in a multicenter trial context, particularly when small sample sizes
  are involved. The flip side of the coin is that even with more
  elaborated procedures, such as combinatorial meta-analysis, possible
  bias is very hard to control, meaning that a good sound meta-analysis
  of poorly designed or conducted studies may well end up in disaster
  (the 'gigo' syndrome, garbage in garbage out). So unless all the
  studies are closely scrutinized and the raw data (not just the
  summary Cmax's and AUC's) are available, I would exercise caution.
  Hope this helps
  
  Luis
  
  ---
  Luis M. Pereira, Ph.D.
  Assistant Professor, Biopharmaceutics and Pharmacokinetics
  Massachusetts College of Pharmacy and Health Sciences
  179 Longwood Ave, Boston, MA  02115
  Phone: (617) 732-2905
  Fax: (617) 732-2228
  Luis.Pereira.-at-.bos.mcphs.edu
  
  

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