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i am a biologist currently testing some novel compounds for
experimental therapy in xenografted nude mice. the test compounds are
lipophillic, and one of the option i have is using cremophorEL as
but there is quite a lot of papers describing non-linear
pharmacokinetics of cremophorEL in mice and humans, with regard to
i would be treating the mice with 50mg/kg bwt for 5 consecutive days,
will this be a cause to be concerned during the experiments?
isn't it advantageous to use cremophorEL as it has a higher Cmax and
low CL values; good for therapeutic effect? OR is there something i
thank you for the patience.
G. Rajesh Kumar, M.Sc.
Department of Inner Medicine
University at Cologne
Building 13 (LFI), Room 4/508
Kerpener Strasse 62
50924 Cologne - Germany
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