PharmPK Discussion - Dose proportionality

• On 11 Dec 2007 at 13:31:50, Madan Kundu (madan4331.-at-.yahoo.co.in) sent the message
  

  
  Hi All,
  
  I just want to clarify myself about Dose proportionality studies. I
  have following specific queries (may be silly):
  1. From the literatures I studied, I observed that Dose
  proportionality assessment has done only in Dose escalation studies.
  Is the dose proportionality assessment always done in Dose escalation
  studies? or separate sutdies can be planned?
  
  2. If we able to establish Dose proportionality then how does it
  affect the dose selection in Phase II trial? If we failed to establish
  dose proportionality then also how does it affect dose selection in
  phase II trial?
  
  Please help me out.
  
  Regards
  Madan Kundu
  
  

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