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The following message was posted to: PharmPK
Dear all, has anyone ever encountered a method for the extraction of
small molecules from plasma in the presence of guanidine? There is
apparently nothing much in the literature.
Thank you for your attention
I.Meineke
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The following message was posted to: PharmPK
Meineke,
I didnt quite get your question but here is reference i came across.
Journal of Chromatography B
Volume 847, Issue 2, 1 March 2007, Pages 133-141
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We use guanidine in an extraction protocol for a PK assay. The method
has been published last year - see Basche et al. Clin Cancer Res
2006:12(18), 5471.
Regards
Keith
Keith Dredge
Manager - Preclinical Development
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