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Dear Colleagues,
Compound GF120918 (a.k.a. GG 918, elacridar, GW918...) is on the list
of the P-gp inhibitors recommended by US FDA.
Does anyone how to obtain this useful compound ? Is there any
commercial source ?
Thanks in advance for your help.
Best regards,
Frederic MASSIERE, PhD
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PharmPK - Discussions about Pharmacokinetics
Pharmacodynamics and related topics
Hi,
these two references would be useful for you
Hyafil, F., Vergely, C., Du Vignaud, P., and Grand-Perret, T. In
vitro and in vivo reversal of multidrug resistance by GF120918, an
acridonecarboxamide derivative.Cancer Res., 53:4595 -4602,1993 .
[Medline - http://mct.aacrjournals.org/cgi/external_ref?
access_num=8402633&link_type=MED]
de Bruin, M., Miyake, K., Litman, T., Robey, R., and Bates, S. E.
Reversal of resistance by GF120918 in cell lines expressing the ABC
half-transporter, MXR.Cancer Lett. , 146:117 -126,1999 .[CrossRef -
http://mct.aacrjournals.org/cgi/external_ref?access_num=10.1016/
S0304-3835%2899%2900182-2&link_type=DOI] [Medline - http://
mct.aacrjournals.org/cgi/external_ref?access_num=10656616&link_type=MED]
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