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The following message was posted to: PharmPK
Dear PK Group Members,
I have a question on the induction of P-glycoprotein by rifampicin?
How long does the induction of P-glycoprotein by rifampicin remain
after discontinuing rifampicin ?
Thank you in advance.
Seong Ryul Kim
Division of Clinical Research & Development
Clinical Pharmacology
Otsuka Pharmaceutical Co., Ltd.
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Dear Kim,
This study may be the answer to your question, at least partially.
"Westphal K, Weinbrenner A, Zschiesche M, Franke G, Knoke M, Oertel
R, Fritz P, von Richter O, Warzok R, Hachenberg T, Kauffmann HM,
Schrenk D, Terhaag B, Kroemer HK, Siegmund W. Related Articles, Links
Induction of P-glycoprotein by rifampin increases intestinal
secretion of talinolol in human beings: a new type of drug/drug
interaction.
Clin Pharmacol Ther. 2000 Oct;68(4):345-55."
Best,
Yusuf Cem Kaplan, MD
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