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Simulations depend on the quality of the initial parameter estimates.
Often enough the distribution of the parameters are normally
distributed. So doing a log transformation of the data can create the
normal dispersion.
My question is how you determine the standard deviation of the log
transformed data. Taking the e^x of the SD data yields information
exceeding the initial data sets parameter max or min.
How do we get to point B?
Dale Bikin, PharmD
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