PharmPK Discussion - Pharmacological availability

• On 27 Aug 2007 at 07:15:10, "Kar N" (research3220.-at-.gmail.com) sent the message
  

  
  Hello,
          I am working with cyanocobalamin formulations at my job.
  While carrying out PK studies I am observing that the pharmacological
  availability and relative bioavailability do not match. Any expert
  view on this ambiguity will be greatly appreciated.
  Thanks in advance.
  Kar N.
  
  

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• On 27 Aug 2007 at 07:24:50, Walter Wolf (wwolfw.-at-.usc.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  To the PK community:
  
  Can somebody give a clear definition (and references) what is meant
  by the term "pharmacological availability" and how such a parameter
  is measured?
  
  In our work, where we measure, using noninvasive imaging methods,
  drug and metabolite concentrations at organ and target  sites, we
  have developed some approaches to correlate that with
  pharmacodynamics. Depending on what is meant by "pharmacological
  availability" it might be usable for PK/PD estimates.
  
  Professor Walter Wolf, Ph.D.
  Distinguished Professor of Pharmaceutical Sciences
  Director, Pharmacokinetic Imaging Program
  Department of Pharmaceutical Sciences, School of Pharmacy
  Chair, Biomedical Imaging Science Initiative
  University of Southern California
  1985 Zonal Ave., Los Angeles, 90089-9121
  E-mail: wwolfw.-a-.usc.edu
  http://www.usc.edu/research/initiatives/bisi/
  http://www.usc.edu/schools/pharmacy/faculty_directory/detail.php?id=59
  
  

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• On 28 Aug 2007 at 08:34:35, "Kar N" (research3220.-a-.gmail.com) sent the message
  

  
  Then a given percentage of pharmacological availability means the
  percentage of drug and metabolites detected at the target sites? Is
  there any good article on this?
  Cheers!!
  Kar N
  
  

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• On 6 Sep 2007 at 20:08:15, "Kar N" (research3220.-a-.gmail.com) sent the message
  

  
  What are the cases when pharmacological availibility is estimated?
  How do they help to judge the effectivess of a formulation apart from
  bioavailability?
  Please comment.
  Kar N
  
  

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