PharmPK Discussion - Pittman Morgan Test and Bioequivalence

• On 26 Mar 2007 at 16:35:48, "sankaratata" (sankaratata.aaa.indiatimes.com) sent the message
  

  
  Dear All,
  I have come across the term Pittman Morgan Test for Bioequivalence
  estimation.
  Can any one explain what this test is for and how it is used. any
  full-text material can be kindly sent to my mail directly.
  
  Thank you in advance
  
  Santosh Tata
  Bioanalytical Division, BEC
  Apotex Inc, Bangalore
  
  

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• On 30 Mar 2007 at 14:20:06, "Hans Proost" (j.h.proost.-at-.rug.nl) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Santosh,
  
  The Pitman-Morgan test is a statistical procedure. It is based on all
  possible permutations of the available data. From these permutations
  the median, confidence interval et cetera are obtained. Its
  application in bioequivalence studies was introduced in the following
  paper:
  
  Haynes JD. Statistical simulation study of new proposed uniformity
  requirement for
  bioequivalency studies.  J Pharm Sci. 1981 Jun;70(6):673-5.
  
  You can find the abstract e.g. in PubMed. Perhaps If you cannot
  obtain a copy of the paper, I have can send you a hardcopy.
  
  Best regards,
  
  Hans Proost
  
  Johannes H. Proost
  Dept. of Pharmacokinetics and Drug Delivery
  University Centre for Pharmacy
  Antonius Deusinglaan 1
  9713 AV Groningen, The Netherlands
  
  Email: j.h.proost.aaa.rug.nl
  
  

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